Preparation of hydrogels by photo-crosslinking of fumaric acid monoethyl ester (fame) functionalized oligomers.
نویسندگان
چکیده
Linear and star-shaped, hydroxy-terminated polyethylene glycol (PEG) and 1,3-trimethylene carbonate (TMC)-based oligomers were functionalized by esterification with fumaric acid monoethyl ester (FAME) in the presence of N,N-dicyclohexyl carbodiimide (DCC) and 4dimethylamino pyridine (DMAP) at room temperature. Networks, designed to release only nontoxic degradation products, were obtained by UV irradiation of the macromers using 2,2-dimethoxy-2-phenylacetophenone (DMPA) as photo-initiator. The swelling properties of the hydrogels in water largely depend on the composition and architecture of the macromers, as well as on the temperature.
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ورودعنوان ژورنال:
- Journal of controlled release : official journal of the Controlled Release Society
دوره 101 1-3 شماره
صفحات -
تاریخ انتشار 2005